National Natural Science Foundation of China 81602103 , Natural Science Foundation of Jiangsu Province BK20160114 , Distinguished Young Scholar Project of Medical Science and Technology Development Foundation of Nanjing Department of Health JQX17005 , Key Project of Medical Science and T81602103;江苏省基础研究计划自然科学基金BK20160114;南京市医学科技发展杰出青年基金JQX17005;南京市医学科技发展一般性课题YKK16114;江苏省卫计委青年课题Q2017007;吴阶平医学基金320.2710.1817