国家重点研发计划2018YFC1315002;国家自然科学基金81803306,81521004,81820108028,81573238;中国香港Kadoorie Charitable基金212946/Z/18/Z,202922/Z/16/Z,104085/Z/14/Z,088158/Z/09/Z;英国Wellcome Trust2018YFC1315002;National Key Research and Development Program of China81803306, 81521004, 81820108028, 81573238;National Natural Science Foundation of China212946/Z/18/Z, 202922/Z/16/Z, 104085/Z/14/Z, 088158/Z/09/Z;Kadoorie Charitable Foundation in Hong Kong of China;Wellcome Trust in the UK