国家传染病防治科技重大专项2017ZX10105011;国家自然科学基金81460520;陕西省自然科学基金2016JM8088,2017JQ8015China Special Grant for the Prevention and Control of Infection Diseases2017ZX10105011;National Natural Science Foundation of China81460520;Natural Science Foundation of Shaanxi Province2016JM8088,2017JQ8015