国家传染病防治科技重大专项2017ZX10105011;国家自然科学基金面上项目81373058;陕西省自然科学基础研究计划项目2017JQ8015;陕西省卫生计生科研基金项目2016A002China Special Grant for the Prevention and Control of Infection Diseases2017ZX10105011;Surface project of National Natural Science Foundation of China81373058;Natural Science Foundation Project of Shaanxi Province2017JQ8015;Shaanxi Provincial Health and Family Planning Research Foundation2016A002