国家自然科学基金81373082;国家科技支撑计划2011BAI09B01;中国香港Kadoorie Charitable基金;英国Wellcome Trust088158/Z/09/Z,104085/Z/14/ZNational Natural Science Foundation of China81373082;National Science and Technology Support Project of China2011BAI09B01;Kadoorie Charitable Foundation in Hong Kong of China;Wellcome Trust in the UK088158/Z/09/Z,104085/Z/14/Z