重庆市卫生计生委医学科研计划项目2016HBRC008,2013-2-140;国家"十二五"科技重大专项2012ZX10001003Medical Research Project of Chongqing Municipal Health and Family Planning Commission2016HBRC008,2013-2-140;National Science and Technology Major Project of China During the 12th Five-year Plan Period2012ZX10001003