浙江省医药卫生科技计划项目2016KYA125;浙江省教育厅一般项目Y201738349;浙江省医药卫生科技计划项目2018KY435 Zhejiang Provincial General Plan for Medical and Health Research2016KYA125;Scientific Research Fund of Zhejiang Provincial Education DepartmentY201738349;Zhejiang Provincial General Plan for Medical and Health Research2018KY435