10.3969/j.issn.1009-6213.2011.06.001
Factor Ⅺ as A Novel Target for Treatment of Thrombotic Disease
Introduction Thrombosis is a major pathological process that threatens human health.It underlies the pathogenesis of the leading causes of death myocardial infarction (MI)and ischemic stroke (IS),as well as life-threatening disseminated intravascular coagulation ( DIC),and deep venous thromboembolism (DVT) and pulmonary embolism.Antithrombosis encompasses several aspects:coagulation,platelets,fibrinolysis,vascular endothelial cells,hemodynamics and hemorheology.Among them,anticoagulation is a fundamental step in antithrombotic therapy.Existing anticoagulants inhibit coagulation factors effectively,and are countered by substantial limitations with severe bleeding risk.For newer generation anticoagulant development,it is important to achieve a low ratio of hemorrhagic risk/antithrombotic benefit.
Treatment、venous thromboembolism、myocardial infarction、pathological process、coagulation factors、endothelial cells、ischemic stroke、development、aspects、major、human、death、step、deep、DIC
17
R364.1(病理学)
2012-03-30（万方平台首次上网日期，不代表论文的发表时间）
共4页
243-246
