陕西省自然科学基础研究计划2015JM8485;西安交通大学第一附属医院临床研究基金XJTU1AHCR2014-039Fund program:Natural Science Foundation of Basic Research Project in Shanxi Province2015JM8485;The Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong UniversityXJTU1AHCR2014-039